Cohesive polydensified matrix hyaluronic acid for the treatment of etched-in fine facial lines: a 6-month, open-label clinical trial.
Black JM, Gross TM, Murcia CL, Jones DH. Dermatol Surg. 2018 Jan 8.; DOI: 10.1097/DSS.0000000000001462


Calcium hydroxylapatite treatment of human skin: evidence of collagen turnover through picrosirius red staining and circularly polarized microscopy.
Zerbinati N, Calligaro A. Clin Cosmet Investig Dermatol. 2018; 11:29–35




Effectiveness evaluation of two volumizing hyaluronic acid dermal fillers in a controlled, randomized, double-blind, split-face clinical study.
Kerscher M, Agsten K, Kravtsov M, et al. Clin Cosmet Investig Dermatol. 2017;10:239–47; DOI:

Free radical scavenging properties of mannitol and its role as a constituent of hyaluronic acid fillers: a literature review.
André P, Villain F.; Int J Cosmet Sci. 2016;1‒6.; DOI: 10.1111/ics.12386

Late-onset inflammatory response to hyaluronic acid dermal fillers.
Bhojani-Lynch T.; Plast Reconstr Surg Glob Open. 2017;5:e1532; DOI: 10.1097/GOX.0000000000001532

Mid-face volumization with hyaluronic acid: injection technique and safety aspects from a controlled, randomized, double-blind clinical study.
Prager W, Agsten K, Kravtsov M, et al. J Drugs Dermatol. 2017;16(4):351‒357

Patient-reported outcomes following split-face injection of 2 volumizing fillers in the upper cheeks.
Prager W, Agsten K, Kerscher M.; Plast Reconstr Surg Glob Open 2017;5:e1412; DOI: 10.1097/GOX.0000000000001412

Two crosslinking technologies for superficial reticular dermis injection: a comparative ultrasound and histologic study.
Micheels P, Besse S, Sarazin D.; J Clin Aesthet Dermatol. 2017;10(1):29‒36. PMCID: PMC5300731

Ultrasound and histologic examination after subcutaneous injection of two volumizing hyaluronic acid fillers: a preliminary study.
Micheels P, Besse S, Sarazin D, et al.; Plast Reconstr Surg Glob Open 2017;5:e1222; DOI: 10.1097/GOX.0000000000001222


A pilot, double-blind, placebo-controlled study to assess the efficacy and safety of incobotulinumtoxinA injections in the treatment of rosacea.
Dayan SH, Ashourian N, Cho K. J Drugs Dermatol. 2017;16(6):549‒54; DOI:

Efficacy and tolerability of incobotulinumtoxinA for treating glabellar frown lines in Korean adults: a postmarketing observational study.
Park JY, Sung NK, Pitt JM.; Dermatol Surg. 2017 Sep 28.; DOI: 10.1097/DSS.0000000000001330

Efficacy of incobotulinumtoxinA for the treatment of glabellar frown lines in male subjects: post-hoc analyses from randomized, double-blind pivotal studies.
Jones DH, Kerscher M, Geister T, et al.; Dermatol Surg. 2017 Nov;43 Suppl 2:S235-S241.; DOI: 10.1097/DSS.0000000000001295

IncobotulinumtoxinA for aesthetic indications: a systematic review of prospective comparative trials.
Prager W, Nogueira Teixeira D, Leventhal PS.; Dermatol Surg. 2017 Apr 3. DOI: 10.1097/DSS.0000000000001076

IncobotulinumtoxinA is an effective and well-tolerated treatment for upper facial lines: results from an open-label extension period of a phase III study.
Trevidic P, Connolly SA, Biwer B, et al. Dermatol Surg. 2017;43 Suppl 3: S285‒S292; DOI: 10.1097/DSS.0000000000001416

Safety of incobotulinumtoxinA in the treatment of facial lines: results from a pooled analysis of randomized, prospective, controlled clinical studies.
Coleman WP 3rd, Sattler G, Weissenberger P, et al. Dermatol Surg. 2017;43 Suppl 3:S293–S303; DOI: 10.1097/DSS.0000000000001409l

Tailored botulinum toxin type A injections in aesthetic medicine: consensus panel recommendations for treating the forehead based on individual facial anatomy and muscle tone.
Anido J, Arenas D, Arruabarrena C, et al.; Clin Cosmet Investig Dermatol. 2017;10:413–421.; DOI: 10.2147/CCID.S138274

Treatment of lateral periorbital lines with different dilutions of incobotulinumtoxinA.
Muti GF, Basso M. J; Clin Aesthet Dermatol. 2017; 10(9):27–29


A multicenter pivotal study to evaluate tissue stabilized-guided subcision using the Cellfina device for the treatment of cellulite with 3-year follow-up.
Kaminer MS, Coleman WP 3rd, Weiss RA, et al. Dermatol Surg. 2017 Jun 28.; DOI: 10.1097/DSS.0000000000001218


Evaluation of a transparent perfluorodecalin-infused patch as an adjunct to laser-assisted tattoo removal: a pivotal trial.
Biesman BS, Costner C.; Lasers Surg Med. 2017 Mar 20.; DOI: 10.1002/lsm.22659


Communication concepts for prevention and early intervention in aesthetic medicine: consensus and literature review.
Gout U, Anand CV, Braz A, et al.;J Drugs Dermatol. 2017;16(9):859‒864

Efficacy and tolerability of incobotulinumtoxinA for treating glabellar frown lines in Korean adults: a postmarketing observational study.
Park JY, Sung NK, Pitt JM.; Dermatol Surg. 2017 Sep 28. DOI: 10.1097/DSS.0000000000001330

First consensus on primary prevention and early intervention in aesthetic medicine.
Landau M, Anand CV, Besins T, et al.;J Drugs Dermatol. 2017;16(9):846‒854

Microfocused ultrasound with visualization and calcium hydroxylapatite for improving skin laxity and cellulite appearance.
Casabona G, Pereira G. Plast Reconstr Surg Glob Open 2017;5:e1388;DOI: 10.1097/GOX.0000000000001388

Pan-Asian consensus— Key recommendations for adapting the World congress of dermatology consensus on combination treatment with injectable fillers, toxins, and ultrasound devices in Asian patients.
Chao YYY, Chhabra C, Corduff N, et al.;J Clin Aesthet Dermatol. 2017;10(7):16‒27


Calcium hydroxylapatite: A review on safety and complications.
Kadouch J.A.; J Cosm Dermatol. 2017; 00:1-10. DOI: 10.1111/jocd.12326

Calcium hydroxylapatite combined with microneedling and ascorbic acid is effective for treating stretch marks.
Casabona G, Marchese P.; Plast Reconstr Surg Glob Open 2017;5:e1474; DOI: 10.1097/GOX.0000000000001474

Diluted calcium hydroxylapatite for skin tightening of the upper arms and abdomen.
Lapatina NG, Pavlenko T.; J Drugs Dermatol. 2017;16(9):900‒906

Microfocused ultrasound in combination with diluted calcium hydroxylapatite for improving skin laxity and the appearance of lines in the neck and décolletage.
Yutskovskaya Y.A., Kogan EA.; J Drugs Dermatol. 2017;16(1):68‒74. PMID: 28095536

Improved neocollagenesis and skin mechanical properties after injection of diluted calcium hydroxylapatite in the neck and décolletage: a pilot study.
Casabona G, Nogueira Teixeira D.; J Cosmet Dermatol. 2017 Dec 29.; DOI: 10.1111/jocd.12475

Restoring jawline contour with calcium hydroxylapatite: a prospective, observational study.
Baspeyras M, Dallara JM, Cartier H, et al. J Cosmet Dermatol. 2017;00:1–6.; DOI: 10.1111/jocd.12335




Effect of different crosslinking technologies on hyaluronic acid behavior: a visual and microscopic study of seven hyaluronic acid gels.
Micheels P, Sarazin D, Tran C et al.; J Drugs Dermatol. 2016;15(5):600–6

Hyaluronic acid fillers with cohesive polydensified matrix for soft-tissue augmentation and rejuvenation: a literature review.
Prasetyo AD, Prager W, Rubin MG, et al.; Clin Cosmet Investig Dermatol 2016;9:257–80; DOI: 10.2147/CCID.S106551

Influence of the macro- and/or microstructure of crosslinked hyaluronic acid hydrogels on the release of two model drugs.
Mondon K, Dadras M, Tillier J, et al.; J Glycobiol 5:119. DOI: 10.4172/2168–958X.1000119

Key importance of compression properties in the biophysical characteristics of hyaluronic acid soft-tissue fillers.
Gavard Molliard S, Albert S, Mondon K; J Mech Behav Biomed Mater. 2016;61:290–8; DOI: 10.1016/j.jmbbm.2016.04.001

Quantifying depth of injection of hyaluronic acid in the dermis: data from clinical, laboratory and ultrasound settings.
Micheels P, Besse S, Sarazin D, et al.; J Drugs Dermatol 2016;15(4):483–90

Safety and performance of CPM® hyaluronic acid fillers with lidocaine in the clinical setting – an open-label, multicenter study.
Kühne U, Esmann J, von Heimburg D, et al.; Clin Cosmet Investig Dermatol 2016;9:373–81; DOI: 10.2147/CCID.S115256


Aesthetic applications of botulinum toxin A in Asians: an international, multidisciplinary, pan-Asian consensus.
Sundaram H, Huang PH, Hsu NJ et al.; Plast Reconstr Surg Glob Open 2016;4:e872; DOI: 10.1097/GOX.0000000000000507

Efficacy and safety of incobotulinumtoxinA in Asian subjects: a pooled analysis of clinical trials in the treatment of glabellar frown lines.
Seo K, Tsai TF, Chao YYY, et al.; J Drugs Dermatol. 2016;15(9):1084–7


Tissue stabilized–guided subcision for the treatment of cellulite: a multicenter pivotal study with two-year follow-up.
Kaminer MS, Coleman WP 3rd, Weiss RA, Grossman J.; Dermatol Surg. 2016;42(10):1213–6; DOI: 10.1097/DSS.0000000000000897


Skin rejuvenation using cosmetic products containing growth factors, cytokines, and matrikines: a review of the literature.
Aldag C, Nogueira Teixeira D, Leventhal PS; Clin Cosmet Investig Dermatol 2016;9:411–9; DOI: 10.2147/CCID.S116158 

A novel matrikine-like micro-protein complex (MPC) technology for topical skin rejuvenation.
Dreher F; J Drugs Dermatol 2016;15(4):457–64


Combining microfocused ultrasound with botulinum toxin and temporary and permanent dermal fillers: safety and current use.
Fabi SG, Goldman MP, Mills DC, et al.; Dermatol Surg 2016;42:S168–S176; DOI: 10.1097/DSS.0000000000000751

Consensus recommendations for combined aesthetic interventions in the face using botulinum toxin, fillers, and energy-based devices.
Carruthers J, Burgess C, Day D, et al.; Dermatol Surg. 2016;42(5):586–97; DOI: 10.1097/DSS.0000000000000754

Consensus recommendations for combined aesthetic interventions using botulinum toxin, fillers, and microfocused ultrasound in the neck, décolletage, hands, and other areas of the body.
Fabi SG, Burgess C, Carruthers A, et al.; Dermatol Surg. 2016;42(10):1199–1208; DOI: 10.1097/DSS.0000000000000869

Validated assessment scales for décolleté wrinkling and pigmentation.
Landau M, Geister TL, Leibou L, et al.; Dermatol Surg 2016;42(7):842–52; DOI: 10.1097/DSS.0000000000000786


Calcium hydroxylapatite with integral lidocaine provides improved pain control for the correction of nasolabial folds.
Schachter D, Bertucci V, Solish N; J Drugs Dermatol 2016;15(8):1005–10

Evaluation of lifting and antiwrinkle effects of calcium hydroxylapatite filler. In vitro quantification of contractile forces of human wrinkle and normal aged fibroblasts treated with calcium hydroxylapatite.
Courderot-Masuyer C, Robin S, Tauzin H, et al.; J Cosmet Dermatol. 2016;15(3):260–8; DOI: 10.1111/jocd.12215

Radiesse®: a novel rejuvenation treatment for the upper arms.
Amselem M; Clin Cosmet Investig Dermatol 2016;9:9–14; DOI: 10.2147/CCID.S93137

Rheological properties of calcium hydroxylapatite with integral lidocaine.
Meland M, Groppi C, Lorenc ZP; J Drugs Dermatol. 2016;15(9):1107–10


Evaluation of micro-focused ultrasound for lifting and tightening neck laxity.
Baumann L, Zelickson B; J Drugs Dermatol. 2016;15(5):607–14



A blinded, randomized, split-face pilot study of bruising and pain with hyaluronic acid for correction of perioral lines using no lidocaine, lidocaine alone, and lidocaine and epinephrine.
Moradi A, Shirazi A, Moradi-Poehler J, et al.; Aesthetic Surg J 2015;35(4):443–55; DOI: 10.1093/asj/sjv043

A prospective, comparative survey to investigate practitioners' satisfaction with a cohesive, polydensified-matrix®, hyaluronic acid-based filler gel with and without lidocaine for the treatment of facial wrinkles.
Prager W, Micheels P; J Cosmet Dermatol 2015;14(2):124–9; DOI: 10.1111/jocd.12136

Cohesive polydensified matrix hyaluronic acid for fine lines.
Sundaram H, Fagien S; Plast Reconstr Surg 2015;136(5 Suppl):149S–63S; DOI: 10.1097/PRS.0000000000001835

Cohesivity of hyaluronic acid fillers: development and clinical implications of a novel assay, pilot validation with a 5-point grading scale, and evaluation of six US FDA-approved fillers.
Sundaram H, Rohrich RJ, Liew S, et al.; Plast Reconstr Surg 2015;136(4):678–86; DOI: 10.1097/PRS.0000000000001638

Hyaluronic acid filler in HIV-associated facial lipoatrophy: evaluation of tissue distribution and morphology with MRI.
Becker M, Balagué N, Montet X, et al.; Dermatology. 2015;230(4):367–74; DOI: 10.1159/000379747

Treatment of age-related mid-face atrophy by injection of cohesive polydensified matrix® (CPM®) hyaluronic acid volumizer.
Micheels P, Vandeputte J, Kravtsov M; J Clin Aesthet Dermatol 2015;8(3):28–34; PMCID: PMC4382143

Ultrastructural analysis of 3 hyaluronic acid soft-tissue fillers using scanning electron microscopy.
Flynn TC, Thompson DH, Hyun SH, et al.; Dermatol Surg 2015;41 Suppl 1:S143–52; DOI: 10.1097/01.DSS.0000452647.14389.a7


A prospective, neurophysiologic comparative study to assess the efficacy and duration of effect of incobotulinumtoxinA and abobotulinumtoxinA in the treatment of crow's feet.
Saybel A, Artemenko A, Nikitin S, et al.; J Drugs Dermatol 2015;14(11):1291–6

A prospective rater- and subject-blinded study comparing the efficacy of incobotulinumtoxinA and onabotulinumtoxinA to treat crow’s feet: a clinical cross-over evaluation.
Muti G, Harrington L; Dermatol Surg 2015;41:S39–S46; DOI: 10.1097/DSS.0000000000000262

A randomized, double-blind trial to investigate the equivalence of incobotulinumtoxinA and onabotulinumtoxinA for glabellar frown lines.
Kane MAC, Gold MH, Coleman WP 3rd et al.; Dermatol Surg 2015;41(11):1310–9; DOI: 10.1097/DSS.0000000000000531

Efficacy and safety of incobotulinumtoxin A for the correction of glabellar lines among patients with skin types IV to VI.
Jackson BA, Vogel MR; J Drugs Dermatol 2015;14(4):350–3

Efficacy and safety of incobotulinumtoxinA in the treatment of upper facial lines: results from a randomized, double-blind, placebo-controlled, phase III study.
Kerscher M, Rzany B, Prager W, et al.; Dermatol Surg 2015;41(10):1149–57; DOI: 10.1097/DSS.0000000000000450

IncobotulinumtoxinA in aesthetics: Russian multidisciplinary expert consensus recommendations.
Yutskovskaya Y, Gubanova E, Khrustaleva I, et al.; Clin, Cosm & Invest Derm 2015;8:297–306; DOI: 10.2147/CCID.S72301

IncobotulinumtoxinA use in aesthetic indications in daily practice: a European multicenter, noninterventional, retrospective study.
Pavicic T, Prager W, Klöppel M, et al.; Clin, Cosm & Invest Derm 2015: 8;135–42; DOI: 10.2147/CCID.S74519

Pharmaceutical, biological, and clinical properties of botulinum neurotoxin type A products.
Frevert J; Drugs R D 2015;15(1):1–9; DOI: 10.1007/s40268-014-0077-1

Patient-reported outcomes after incobotulinumtoxinA treatment for upper facial wrinkles.
Streker M, Luebberding S, Krueger N, et al.; Dermatol Surg 2015;41:S29–S38; DOI: 10.1097/DSS.0000000000000274

IncobotulinumtoxinA for the treatment of platysmal bands: a single-arm, prospective proof-of-concept clinical study.
Prager W, Bee EK, Havermann I, et al.; Dermatol Surg 2015;41:S88–S92; DOI: 10.1097/DSS.0000000000000177


A randomized study to validate the Merz hand grading scale for use in live assessments.
Cohen JL, Carruthers A, Jones DH, et al.; Dermatol Surg 2015;41 Suppl 1:S384-8; DOI: 10.1097/DSS.0000000000000553

Consensus recommendations for optimal augmentation of the Asian face with hyaluronic acid and calcium hydroxylapatite.
Rho NK, Chang YY, Chao YY, et al.; Plast Reconstr Surg 2015;136(5):940–56; DOI: 10.1097/PRS.0000000000001706


Evaluation of the Merz hand grading scale after calcium hydroxylapatite hand treatment.
Bertucci V, Solish N, Wong M, et al.; Dermatol Surg 2015 Dec;41 Suppl 1:S389-96; DOI: 10.1097/DSS.0000000000000546

A prospective, comparative, evaluator-blind clinical study investigating efficacy and safety of two injection techniques with Radiesse® for the correction of skin changes in aging hands.
Gubanova EI, Starovatova PA; J of Cutan & Aesthetic Surg 2015;8(3):147–52; DOI: 10.4103/0974-2077.167271

Calcium hydroxylapatite for augmentation of face and hands: a retrospective analysis in Italian subjects.
Muti GF, Astolfi G, Renzi M, et al.; J Drugs Dermatol 2015; 14(9):948–54

Body vectoring technique with Radiesse® for tightening of the abdomen, thighs and brachial zone.
Cogorno Wasylkowski V; Clin, Cosm & Invest Derm 2015;8:267–73; DOI: 10.2147/CCID.S75631

Complete biodegradable nature of calcium hydroxylapatite after injection for malar enhancement: an MRI study.
Pavicic T; Clin, Cosm & Invest Derm 2015:8 19–25; DOI: 10.2147/CCID.S72878

Calcium hydroxylapatite: Over a decade of clinical experience.
Loghem JV, Yutskovskaya YA, Werschler P; J Clin Aesthet Dermatol 2015;8(1):38–49; PMCID: PMC4295857

Last modified: Friday, 16 February 2018, 5:44 PM